A conserved AU‐rich element in the 3’ untranslated region ofbcl‐2 mRNA is endowed with a destabilizing function that is involved inbcl‐2 down‐regulation during apoptosis
- 1 January 2000
- journal article
- Published by Wiley in The FASEB Journal
- Vol. 14 (1) , 174-184
- https://doi.org/10.1096/fasebj.14.1.174
Abstract
The control of mRNA stability is becoming recognized as a crucial point of gene expression regulation. A common element responsible for mRNA decay modulation is the adenine- and uracil-rich element...Keywords
Funding Information
- Institut National de la Santé et de la Recherche Médicale
This publication has 49 references indexed in Scilit:
- RNA stabilization by the AU-rich element binding protein, HuR, an ELAV proteinThe EMBO Journal, 1998
- K-ras modulates the cell cycle via both positive and negative regulatory pathwaysOncogene, 1997
- Human cytokines suppress apoptosis of leukaemic CD5+ B cells and preserve expression of bcl‐2Immunology & Cell Biology, 1997
- Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosisLeukemia, 1997
- Plasminogen Activator Inhibitor Type 2 Gene Induction by Tumor Necrosis Factor and Phorbol Ester Involves Transcriptional and Post-transcriptional EventsJournal of Biological Chemistry, 1996
- Interleukin-7 rescues human activated T lymphocytes from apoptosis induced by glucocorticoesteroids and regulates bcl-2 and CD25 expressionHuman Immunology, 1995
- Tumor necrosis factor-α up-regulates Bcl-2 expression and decreases calcium-dependent apoptosis in human B cell linesInternational Immunology, 1995
- New insights into the auxiliary domains of eukaryotic RNA binding proteinsFEBS Letters, 1994
- Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell deathCell, 1991
- Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocationCell, 1986