A group of thermodynamic potentials applicable to ligand binding by a polyfunctional macromolecule.
Open Access
- 1 April 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (4) , 1464-1468
- https://doi.org/10.1073/pnas.72.4.1464
Abstract
The binding of ligands by a macromolecule can be well described by a group of potentials derivable from the energy and of which the original binding potential is one. The group is Abelian and is isomorphic with a group of symmetries. Each member corresponds to a particular set of experimental conditions--system open to some, closed to others, of the ligand-and the group as a whole is an immediate source of all possible linkage relations applicable to the macromolecule. Seen in terms of information theory it can be interpreted as a program for the response of the macromolecule to its ligands according to the conditions with which it is faced. The group provides a ready formulation of the effect of a ligand on the equilibrium constant for a reaction involving a set of macromolecules, and it leads to a clear-cut distinction between true and pseudolinkage.Keywords
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