Tatumine, a peptide from Bacillus brevis Vm4-572-403.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (4) , 359-363
- https://doi.org/10.7164/antibiotics.33.359
Abstract
The mutant 572-403 of B. brevis Vm4 was isolated from N-methyl-N''-nitro-nitroso guanidine (nitrosoguanidine)-treated cultures of the parental strain. The mutant produces tatumine and edeine B when grown in a defined medium at 40.degree. C. Tatumine is composed of spermidine, glycine, isoserine and an unidentified ninhydrin-positive compound; it has a MW < 703 (edeine A). It is soluble in water and isopropanol. Tatumine has no antimicrobial activity but has selective cytotoxicity against cultured cells of sarcoma origin. This activity is not destroyed by heating for 1 h at 60.degree. C.This publication has 1 reference indexed in Scilit:
- On the Chemical Nature of the Antibiotic Edeine*Biochemistry, 1966