Late Clinical and Laboratory Manifestations of Thorotrast Administration in Cerebral Arteriography

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Abstract
Thirty patients who received thorotrast for cerebral arteriography from 1948 to 1952 were studied to determine the delayed effects of chronic low-dose internal-emitter radiation. The whole-body burdens ranged from 0.13 to 2.5 gram-equivalents of radioactive thorium and varied with the total amount of thorotrast originally administered. Bromsulfalein retention ranged from 5 to 27 per cent, and alkaline phosphatase from 4.7 to 9.8 units in over half the patients. Most had a moderate relative increase in the albumin and a decrease in the globulin fraction on serum protein electrophoresis. Only three patients had completely normal results on liver-function tests. Chromosome analyses of white blood cells revealed chromosomal breaks and abnormalities in nine of 10 patients.
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