Spectrophotometric Determination of Amoxycillin in Dosage Forms

Publisher Website
Google Scholar
Abstract
Two spectrophotometric methods are proposed for the determination of amorycillin and its doeage fonne. Both procedures depend on the phenolic nature of the compound. The first method is based on condeneation with 4-aminoautipyrine in the presence of an alkaline oxidising agent. A red coloured antipyrine dye peaking at 500 nm. is produced. The second method involves the use of folin's reagent, a blue colour with λ max at 670 nm is obtained. The proposed methods could be applied successfully for the determination of dosage forms containing amoxycillin, and the results obtained were compared favourably with those obtained with the official methods.