Leukemia induction in C3H mice following their inoculation with normal AKR lymphoid cells

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Abstract
Newborn C3H mice were injected with viable or in vitro X‐irradiated cell suspensions from lymph node and spleen mixtures obtained from healthy AKR donors aged 12 to 18 months. Of the group injected with normal intact cells, 30% developed a lymphocytic leukemia, whereas none of the recipients of irradiated cells did so. Genetic analysis showed that the leukemias appearing in C3H mice originated de novo in the recipient animals apparently as a result of their inoculation with immunocompetent lymphoid cells. The results obtained by using this model of leukemia induction are discussed on the basis of participation of a graft‐versus‐host reaction in this process.