Nonsteroidal Anti-Inflammatory Drugs

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Abstract
THE nonsteroidal anti-inflammatory agents include some of the most widely used drugs in the Western world. Although their number is constantly being augmented by pharmaceutical research, relatively few of the agents that have been demonstrated to have anti-inflammatory activity are clinically useful. Many, but not all, of the agents also have valuable analgesic and antipyretic effects. Although it is probable that each of these actions is brought about by related mechanisms, in this review their anti-inflammatory activity will be considered primarily.Of the many conditions for which nonsteroidal anti-inflammatory agents are used, the rheumatic diseases are the most serious. Because . . .