Evidence for an enterotropic homone: Compensatory hyperplasia in defunctioned bowel

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Abstract
The relative contributions of luminal and systemic factors to the development of compensatory intestinal hyperplasia were assessed by comparing the adaptive response to jejunal resection in functioning and defunctioned ileum. In Thiry-Vella loops of upper ileum, mucosal contents of RNA and DNA increased by 16–21 per cent 2–7 days after jejunectomy (P=0·05–0·01), but DNA specific activity was unchanged, In lower ilcum remaining in continuity with the nutrient stream, nucleic acids were elevated by 27–86 per cent (P<0·001) and specific activity by 34–36 per cent (P=0·05–0·005). Proximal to the site of resection, duodenal hyperplasia was equally rapid but less intense than in the distal bowel, Full adapation requires both intraluminal nutrients and enterotropic homones to be present.