REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS

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Abstract
Following repeated intracutaneous injections of heat-killed pneumococci, rabbits acquire an increased skin reactivity, which reaches a maximum after 4-6 injections, after which it greatly diminishes; its relationship to active resistance to infection by pneumococci, and to presence of species-specific antibodies in the blood, is still obscure. The increased skin reactivity is not transferable by serum from highly reactive to normal rabbits. After regression of the reaction to the first intracutaneous injection of pneumococci, there frequently follows a recrudescence, or exacerbation, of the reaction. The increased skin reactivity and secondary reactions are incited alike by all types and forms of pneumococci.

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