ALPHA-1 ADRENERGIC CONTROL OF THE VENOUS CIRCULATION IN INTACT DOGS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 233  (3) , 729-734
Abstract
Dogs (17) were lightly sedated and instrumented with thermodilution pulmonary flow and aortic catheters to study a adrenergic control of venous circulation. Hemodynamics, cardic output and central blood volume were measured at rest. Mean circulatory filling pressure, pressure diet for venous return and resistance to venous return were calculated from pressures obtained during transient acetylcholine-induced circulatory arrest. Phenylephrine was then infused at 2 steady-state level to increase mean aortic pressure by 50 and 100% above control values. Heart rate was controlled with atropine. Phenylephrine increased (P < .025) mean aortic pressure from 80.7 .+-. 2.9-121.3 .+-. 7.6-164.7 .+-. 6.1 mm Hg and systemic vascular resistance from 23.3 .+-. 2.0-32.2 .+-. 3.5-43.5 .+-. 4.1 mm Hg/min per ml and did not change cardiac output (161.9 .+-. 12.6-175.6 .+-. 13.8-169.6 .+-. 11.9 ml/min per kg). Mean circulatory filling pressure increased from 7.1 .+-. 0.5-9.7 .+-. 0.6-13.2 .+-. 1.3 mm Hg (P < .025). Pressure gradient for venous return increased from 6.4 .+-. 0.4-7.7 .+-. 0.4-8.9 .+-. 0.4 mm Hg (P < .025). Central blood volume increased from 162. .+-. 0.9-19.4 .+-. 1.4-22.0 .+-. 1.9 ml/kg (P < .025). To eliminate reflex changes in vascular tone, 8 dogs received ganglionic blockade with trimethaphan. After ganglionic blockade phenylephrine increased cardiac output, systemic vascular resistance, mean circulatory filling pressure, pressure gradient for venous return and central blood volume (P < .025). In conscious dogs, phenylephrine reduces peripheral vascular capacitance and shift blood from the venous circulation to the central and arterial vascular compartments.

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