CHARACTERIZATION OF A SPONTANEOUS MURINE B-CELL LEUKEMIA (BCL1) .1. CELL-SURFACE EXPRESSION OF IGM, IGD, IA, AND FCR

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 123  (3) , 992-999
Abstract
The surface marker expression of a spontaneous B [bone marrow-derived] lymphocyte leukemia discovered in a BALB/c mouse (BCL1) included a subset of markers that occur on normal B lymphocytes. The tumor cells bore surface Ig [immunoglobulin] that included .mu.- and .delta.-chains associated with the .lambda. L chain. Alloantigens coded for within the murine MHC [major histocompatibility complex], including H-2D, H-2K and I-region products, were identified on the tumor cells. Although normal B lymphocytes may express products coded for within the I-A and I-E subregions, the BCL1 expressed only normal amounts of I-E subregion products. The H-2 and Ia antigens revealed by 2-dimensional gel electrophoresis exhibited an abnormal pattern of post-translational modifications. The Fc but not the complement-receptor was present on the surface of tumor cells. The presence of IgD, Ia antigens and the responsiveness to [Escherichia coli] lipopolysaccharide indicate that the BCL1 tumor represents a later differentiative stage than murine B lymphocyte tumors previously described.