Reaction of Indoles with Electron Deficient Olefins Catalyzed by Yb(OTf)3⋅3H2O
- 1 November 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (11) , 1047-1048
- https://doi.org/10.1055/s-1996-5685
Abstract
Treatment of indoles with a variety of electron deficient olefins under the influence of Yb(OTf)3⋅3H2O leads to alkylation of the indoles at the 3-position in moderate to excellent yields. This mild coupling procedure may offer a convenient entry into the hapalindole class of marine alkaloids.Keywords
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