Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors
Open Access
- 28 August 2009
- journal article
- Published by Springer Nature in Immunity & Ageing
- Vol. 6 (1) , 11
- https://doi.org/10.1186/1742-4933-6-11
Abstract
Ageing is associated with changes in the immune system with substantial alterations in T-lymphocyte subsets. Cytomegalovirus (CMV) is one of the factors that affect functionality of T cells and the differentiation and large expansions of CMV pp65-specific T cells have been associated with impaired responses to other immune challenges. Moreover, the presence of clonal expansions of CMV-specific T cells may shrink the available repertoire for other antigens and contribute to the increased incidence of infectious diseases in the elderly. In this study, we analyse the effect of ageing on the phenotype and frequency of CMV pp65-specific CD8 T cell subsets according to the expression of CCR7, CD45RA, CD27, CD28, CD244 and CD85j.Keywords
This publication has 62 references indexed in Scilit:
- Age-Dependent Association between Low Frequency of CD27/CD28 Expression on pp65 CD8+T Cells and Cytomegalovirus Replication after TransplantationClinical and Vaccine Immunology, 2009
- Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individualsClinical and Experimental Immunology, 2009
- Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adultsImmunity & Ageing, 2008
- Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old peopleImmunity & Ageing, 2008
- T cell subset-specific susceptibility to agingClinical Immunology, 2008
- Cytomegalovirus infection induces T‐cell differentiation without impairing antigen‐specific responses in Gambian infantsImmunology, 2008
- CMV pp65 and IE-1 T cell epitopes recognized by healthy subjectsJournal of Translational Medicine, 2007
- Role of persistent CMV infection in configuring T cell immunity in the elderlyImmunity & Ageing, 2007
- CD4+ CD8+ T cells in young and elderly humans. Comment on Macchia I, Gauduin MC, Kaur A, Johnson RP. Expression of CD8α identifies a distinct subset of effector memory CD4+ T lymphocytes. Immunology 2006; 119:232–42Immunology, 2007
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999