Hemodynamic Effects of Renal Transplants in Hypertensive and Control Rats.
- 1 January 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 115 (1) , 4-8
- https://doi.org/10.3181/00379727-115-28813
Abstract
Summary Transplantation of a normal kidney to a renal hypertensive rat produced a decrease in mean arterial pressure of 171 to 138 mmHg and a decrease in cardiac output from 258.9 to 167.3 ml/kg/min. There was no significant change in calculated total peripheral resistance or in regional vascular resistance in the perfused hind leg. The decrease in mean arterial pressure is caused by a decrease in cardiac output resulting from a decrease in stroke volume. Kidney transplantation to a normal rat elicits a lesser decrease in mean arterial pressure, which is caused by a decrease in both cardiac output and in total peripheral resistance.Keywords
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