A multiple sequence alignment program
Open Access
- 1 January 1986
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 14 (1) , 363-374
- https://doi.org/10.1093/nar/14.1.363
Abstract
A program1 is described for simultaneously aligning two or more molecular sequences which is based on first finding common segments above a specified length and then piecing these together to maximize an alignment scoring function. Optimal as well as near-optimal alignments are found, and there is also provided a means for randomizing the given sequences for testing the statistical significance of an alignment. Alignments may be made in the original alphabets of the sequences or in user-specified alternate ones to take advantage of chemical similarities (such as hydrophobic-hydrophilic).Keywords
This publication has 3 references indexed in Scilit:
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- Simultaneous comparison of three protein sequences.Proceedings of the National Academy of Sciences, 1985
- An efficient method for finding repeats in molecular sequencesNucleic Acids Research, 1983