IMAGING ADRENAL-GLANDS WITH RADIOLABELED INHIBITORS OF ENZYMES - CONCISE COMMUNICATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (2) , 200-203
Abstract
Although radioiodinated cholesterols furnished the 1st noninvasive imaging of the adrenal glands, it would be desirable to decrease the time for imaging and decrease the radiation dose. The relative tissue distributions of 2 radiolabeled enzyme inhibitors [3H] metyrapol and 125I-SKF-12185 were studied in dogs and man. Their percentage uptakes and target-to-nontarget ratios were similar. The adrenals of 3 dogs were imaged sharply at 2 h after injection with 4-6 mCi of 131I-SKF-12185, confirmed by subsequent imaging with 1 mCi of 131I-6-.beta.-19-nor cholesterol at 5 days after injection. The use of 1 mCi of 123I-SKF will permit imaging of the adrenals in 1-2 h and will decrease the radiation dose in the human to 0.76 rads to the adrenal, 0.18 rads to the ovaries and 1.7 rads to the liver.

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