Association of Stiff-man Syndrome and Type I Diabetes With Islet Cell and Other Autoantibodies

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Abstract
To the Editor. —We report a case of association between stiff-man syndrome, type I diabetes, and autoimmune polyendocrine/organ-specific serologic findings. Report of a Case. —A 49-year-old obese woman was admitted in January 1983 because of stiffness of the lower back, thighs, and legs, and intermittent painful muscle spasms of the entire body: spasmodic muscle contractions occurred spontaneously and lasted for several minutes. Clinical and electromyographic studies were diagnostic for stiff-man syndrome, a rare neurologic disorder of unknown etiology. This condition is characterized by fluctuating rigidity of axial and limb muscles due to continuous muscle fiber spasm, without signs of cerebral and spinal cord impairment, and with continuous electromyographic activity.1At that time fasting serum glucose concentration was normal. She was treated with diazepam, with remarkable improvement. In August 1985, she was admitted to the intensive care unit because of ketoacidotic coma. Her personal and family history were unremarkable

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