First phase I clinical trial of an HIV-1 subtype D gp140 envelope protein vaccine: immune activity induced in all study participants
- 2 January 2008
- journal article
- clinical trial
- Published by Wolters Kluwer Health in AIDS
- Vol. 22 (1) , 149-151
- https://doi.org/10.1097/qad.0b013e3282f174ed
Abstract
To combat HIV-1 diversity, we are developing a multienvelope vaccine (comprising DNA, vaccinia virus and protein vectors). Toward this goal, we conducted a phase I clinical trial of EnvPro, a gp140 protein formulated in alum. The vaccine was well tolerated and elicited an immune response in every trial participant.Keywords
This publication has 14 references indexed in Scilit:
- Multi-envelope HIV-1 vaccine devoid of SIV components controls disease in macaques challenged with heterologous pathogenic SHIVVaccine, 2005
- Long lived multi-isotype anti-HIV antibody responses following a prime-double boost immunization strategyVaccine, 2004
- Subcutaneous Administration of a Recombinant Vaccinia Virus Vaccine Expressing Multiple Envelopes of HIV-1European Journal of Clinical Microbiology & Infectious Diseases, 2004
- Human Immunodeficiency Virus (HIV) Seropositivity among Uninfected HIV Vaccine RecipientsThe Journal of Infectious Diseases, 2003
- Immunogenicity of hepatitis B vaccines: implications of immune memoryVaccine, 2002
- A novel vaccine regimen utilizing DNA, vaccinia virus and protein immunizations for HIV-1 envelope presentationVaccine, 1999
- Screening of HIV-1 Env Glycoproteins for the Ability to Raise Neutralizing Antibody Using DNA Immunization and Recombinant Vaccinia Virus BoostingVirology, 1997
- Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and CharacterizationJournal of Virology, 1996
- Inter- and intraclade neutralization of human immunodeficiency virus type 1: genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypesJournal of Virology, 1996
- Fidelity of HIV-1 Reverse TranscriptaseScience, 1988