THE ENHANCEMENT OF HAEMOPOIETIC STEM CELL RECOVERY IN IRRADIATED MICE BY PRIOR TREATMENT WITH CYCLOPHOSPHAMIDE

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Abstract
Studies are reported of the enhancement of [mouse] stem cell recovery following whole body irradiation as a result of prior administration of cyclophosphamide. The much larger enhancement of regeneration observed for the hosts own surviving stem cells, compared to the regeneration of injected bone marrow stem cells, is due to the different numbers of stem cells initiating the regeneration in conjunction with the time course of stem cell regeneration. The environmental changes produced by cyclophosphamide greatly enhance hemopoietic recovery even though at the dose used this agent is relatively toxic to stem cells. The level of stem cell regeneration is nearly independent of the .gamma.-ray dose in the range 3-8 gray (300-800 rad). If human bone marrow responds similarly, regeneration produced by cytotoxic drugs administered prior to radiation would probably embody a considerable safety factor as far as recovery of the hemopoietic system is concerned [after cancer therapy].
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