Transforming growth factor‐β1 rapidly activates phosphorylase in a calcium‐dependent manner in rat hepatocytes
- 12 October 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 311 (1) , 37-40
- https://doi.org/10.1016/0014-5793(92)81361-o
Abstract
Transforming growth factor-beta 1 (TGF-beta 1) rapidly activated phosphorylase in isolated rat hepatocytes (half-maximal rate of activation with approximately 0.1 ng/ml). Removal of Ca2+ from the external medium just before TGF-beta 1 addition markedly attenuated phosphorylase activation. TGF-beta 1 (1 ng/ml) produced a small increase in [Ca2+]i (approximately 10% increase after 30 s), which appears sufficient to account for phosphorylase activation. These observations indicate that activation of the TGF-beta 1 signal transduction system in hepatocytes is linked with a small increase in [Ca2+]i, and external Ca2+ may contribute in part to this increase.Keywords
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