Failure of Topical Prostaglandin Inhibitors to Improve Wound Healing following Deep Partial-thickness Burns

Publisher Website
Google Scholar
Abstract
The present study was designed to determine the efficacy of topical inhibitors of prostaglandins on wound healing. Two uniform deep partial-thickness burns were inflicted on mirror-image areas of guinea pig backs by an aluminium template heated to 75.degree. C and applied for 10 s. Indomethacin was tested extensively in a wide range of concentrations in groups of 6 or more animals each. The healing rates measured at 21 days postburn showed that topical indomethacin at each concentration tested was not effective for improving wound healing. The treated sites were consistently worse than the control sites. The drug adversely affected the healing process proportional to the concentration and was associated with death, which was related to performations of the GI tract. The India ink filling in the dermal microcirculation was no better in the experimental wounds than in the controls. The evaluations for hair growth were definitely in favor of the controls. The other tested inhibitors, ibuprofen, flurbiprofen, tolmetin, zomepirac, piroxicam and dipyridamole, also failed to show any benefit.