CORRELATION OF RATE OF GROWTH WITH HISTOLOGIC CHARACTERISTICS OF BASAL CELL CARCINOMA

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Abstract
INTEREST in basal cell carcinoma of the skin has, in the past, been evidenced principally in studies relative to the histogenesis of the tumor.1 Although isolated statements have been made concerning variations in biologic behavior, opinions have been empirical, based on clinical observation rather than on statistically proved data. The present study is concerned with attempts to associate biologic behavior of basal cell carcinoma with variations in histologic architecture. Clinically, basal cell carcinoma may exhibit widely varying rates of growth. On the one hand, a small, circumscribed, nonulcerated lesion may have been present for a number of years and may well merit the term nevus or hamartoma.1f On the other hand, a lesion with a similar histologic picture may progress slowly but inexorably, with eventual invasion and destruction of large areas of tissue. Lack of ability to metastasize is, as yet, not satisfactorily explained. REVIEW OF THE LITERATURE Although previous studies on basal cell carcinoma have resulted in many morphologic

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