Myoglobin and Creatine Kinase Release in Coronary Care Patients without Acute Myocardial Infarction

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Abstract
Fifty‐nine consecutive coronary care patients, clinically evaluated as not having acute myocardial infarction (AMI) and with a duration of symptoms of less than 6 hours on admission, were studied. Serum myoglobin (MG) and creatine kinase (CK) were determined sequentially during the first 24 hours. Two groups were identified, one with a pattern of a serum MG peak followed by a CK peak and one without. Twenty‐four patients had a serum MG peak of 137±33 μg * 1‐1 followed by a CK peak of 1.6±0.9 μkat * 1‐1. Values above the reference limits were found in 19 patients for MG and in 5 for CK. After the onset of symptoms, the peaks were observed at 5.3±2.8 (MG) and 12.7±5.3 (CK) hours. Compared to the group without MG and CK peaks, ECG alterations were more frequent in the group with peaks, 20/24 (84%) versus 15/35 (43 %), The entire patient group had the same 2‐year incidence of major coronary events as patients with AMI, but it tended to be higher in patients with MG/CK release.