Scw1p Antagonizes the Septation Initiation Network To Regulate Septum Formation and Cell Separation in the Fission Yeast Schizosaccharomyces pombe

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Abstract
Cytokinesis in the fission yeast Schizosaccharomyces pombe is regulated by a signaling pathway termed the septation initiation network (SIN). The SIN is essential for initiation of actomyosin ring constriction and septum formation. In a screen to search for mutations that can rescue the sid2 - 250 SIN mutant, we obtained scw1 - 18 . Both the scw1 - 18 mutant and the scw1 deletion mutant ( scw1 Δ mutant), have defects in cell separation. Both the scw1 - 18 and scw1 Δ mutations rescue the growth defects of not just the sid2 - 250 mutant but also the other temperature-sensitive SIN mutants. Other cytokinesis mutants, such as those defective for actomyosin ring formation, are not rescued by scw1 Δ. scw1 Δ does not seem to rescue the SIN by restoring SIN signaling defects. However, scw1 Δ may function downstream of the SIN to promote septum formation, since scw1 Δ can rescue the septum formation defects of the cps1 - 191 β-1,3-glucan synthase mutant, which is required for synthesis of the primary septum.

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