Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 6 (2) , 433-441
- https://doi.org/10.1002/j.1460-2075.1987.tb04773.x
Abstract
Genomic and cDNA clones encoding a Drosophila melanogaster protein kinase C (PKC) homologue were identified using a bovine PKC cDNA probe. The cDNA clones contain a single open reading frame that encodes a 639 amino acid, 75‐kd protein having extensive homology with bovine, human and rat PKC and homology with the kinase domains of other serine, threonine and tyrosine kinases. The Drosophila PKC gene is localized to region 53E of chromosome 2. The gene spans approximately 20 kb and contains at least 14 exons. Messenger RNA for PKC could not be detected in 0‐3 h Drosophila embryos. Adult flies contain three PKC transcripts of 4.3, 4.0 and 2.4 kb.This publication has 72 references indexed in Scilit:
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