INTRACELLULAR COLLAGEN FIBRILS IN PROLAPSED (FLOPPY) HUMAN ATRIOVENTRICULAR VALVES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (5) , 439-443
Abstract
Ultrastructural study of prolapsed atrioventricular valves from 5 patients, 1 of whom also had Marfan''s syndrome, disclosed granular cells that were characterized by numerous membrane-bound, electron-dense inclusions resembling those in Hurler''s syndrome. Collagen fibrils were present within some of these inclusions. The intracellular collagen deposits may form as a consequence of abnormal interactions between newly secreted collagen and acid mucopolysaccharides.

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