PURPURA AS A MANIFESTATION OF PENICILLIN SENSITIVITY

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Abstract
Three cases of purpura were seen in association with the delayed serum sickness pattern of penicillin sensitivity. One of the 3 patients was atopic. Other cases of nonthrombocytopenic purpura were ruled out. The purpura subsided with the other symptoms with cessation of penicillin therapy. The positive tourniquet test in these cases of purpura probably indicates that the capillaries are in such a state of response that not only is transudation of serum permitted, but also there occurs the actual passage of blood cells through the capillary walls. The negative laboratory findings with reference to the clotting mechanism of the blood, in association with the positive tourniquet tests probably reflect a more violent and advanced degree of capillary permeability produced as a result of this allergic mechanism.

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