THE CEREBRAL CIRCULATION

1 October 1929

journal article
other
Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry

Vol. 22 (4) , 691-694
https://doi.org/10.1001/archneurpsyc.1929.02220040046004

Abstract

Different investigators seem to have obtained different results from the intravenous injection and local application of solution of pituitary, U. S. P. Dixon and Halliburton,¹in brain perfusion experiments on dogs, found that pituitary at first constricted and then dilated cerebral arteries. Cow,²using rings or sections of surviving cerebral arteries of various animals, found that pituitary caused constriction. Raphael and Stanton³measured the changes in the volume of the brain and the pulse through a defect in the skull in man. They concluded that pituitary given intravenously caused cerebral dilatation. Florey⁴directly observed the cerebral surface (both the convexity and the base) of cats, and observed no change in the size of the cerebral arteries on either intravenous injection or local application of pituitary. Sandor,⁵on studing cerebral blood vessels in the frog by direct microscopic observation, found that pituitary caused constriction which was followed by dilatation. Howe and McKinley⁶noted no change in cerebral arteries in cats after the intravenous injection of pituitary extract.

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