Sex Differences in the Cyclic Adenosine 3′:5′-Monophosphate and Growth Hormone Response to Growth Hormone-Releasing Factor In Vitro

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Abstract
Human pancreas tumor growth hormone-releasing factor (hpGRF) induced more cellular cAMP accumulation and growth hormone release from male than female rat anterior pituitaries in vitro. This was reflected in a change in maximal levels achieved (efficacy) rather than potency, and was not an exclusive effect of hpGRF peptide; prostaglandin E2 also exhibited these effects. The origin of the larger spontaneous peak growth hormone levels in male rats may be within the anterior pituitary gland.