Erythrocyte ghosts (Na++K+) ATPase activity in duchenne's dystrophy and myotonia
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Neurologie
- Vol. 214 (1) , 61-69
- https://doi.org/10.1007/bf00313489
Abstract
In Duchenne muscular dystrophy the activity of (Na++K+) ATPase in erythrocyte ghosts is reduced and its reaction to ouabain is paradoxical both in low sodium and high sodium systems. No such changes were seen in a case of Becker dystrophy, in limb-girdle dystrophy, and in neurogenic atrophy of muscles. In myotonic dystrophy and congenital myotonia the activity of ATPase and its inhibition by ouabain were depressed. Die Aktivität der Na+ und der K+ aktivierbaren ATP-ase der Erythrocyten ist in Fällen von Duchenne'scher Muskeldystrophie vermindert. Ihre Reaktion auf Ouabain ist sowohl in einem System mit niedrigen wie in einem System mit hohem Natriumgehalt in paradoxer Weise verändert, indem sie aktiviert wird, während sie in Fällen von Becker'scher Dystrophie und von Dystrophie vom Rumpfgürtel-Typus sowie in neurogenen Muskelatrophien gehemmt wird. Bei der myotonischen Dystrophie und der kongenitalen Myotonie ist die Aktivität der ATP-ase vermindert und weniger gehemmt.Keywords
This publication has 56 references indexed in Scilit:
- Comparative electron spin resonance study of the erythrocyte membrane in myotonic muscular dystrophyBiochemistry, 1974
- Electron Spin Resonance Studies of Erythrocytes from Patients with Myotonic Muscular DystrophyProceedings of the National Academy of Sciences, 1974
- Activation energy and phospholipid requirements of membrane-bound adenosine triphosphatasesArchives of Biochemistry and Biophysics, 1973
- Demonstration of a Phosphopeptide Intermediate in the Mg ++ -Dependent, Na + - and K + -Stimulated Adenosine Triphosphatase Reaction of the Erythrocyte MembraneProceedings of the National Academy of Sciences, 1972
- The role of cations and other factors on the apparent energy of activation of (Na+ + K+)-ATPaseArchives of Biochemistry and Biophysics, 1971
- Ouabain and Erythrocyte-Ghost Adenosine TriphosphataseArchives of Neurology, 1971
- Erythrocyte Abnormality in Human MyopathyScience, 1967
- Glycoside effect upon membrane enzymes of erythrocytes and muscle in duck myopathyCellular and Molecular Life Sciences, 1967
- A characterization of the ouabain sensitivity of heart microsomal ATPaseBiochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis, 1966
- Activity patterns of purified ATPase from Arachis hypogaeaLife Sciences, 1965