Effects of diphosphonate and X-Rays on bone lesions induced in rats by prostate cancer cells
- 15 May 1988
- Vol. 61 (10) , 2027-2032
- https://doi.org/10.1002/1097-0142(19880515)61:10<2027::aid-cncr2820611017>3.0.co;2-j
Abstract
Prostate adenocarcinoma-III (PA-III) cells deposited over the scapula of Lobund-Wistar (L-W) rats induced osteolytic and osteoplastic changes in that bone. The osteolytic process was prevented and interrupted by administrations of dichloromethylene diphosphonate (Cl2MDP); but the osteoplastic process, once initiated, continued. The latter process was interrupted by ionizing radiation. Treatments of PA-III-affected bones with Cl2MDP and x-rays immobilized both osteolytic and osteoplastic processes.This publication has 10 references indexed in Scilit:
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