Electrical characteristics of the isolated dog ciliary body

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Abstract
Transepithelial potential difference and short-circuit current of the dog ciliary body were measured in vitro in an Ussing-type chamber using HEPES[N-2-hydroxyethylpiperazino-N''-2-ethane sulfonic acid]-buffered solution containing bicarbonate. Their values were -1.35 .+-. 0.08 mV (mean .+-. SEM, n = 52) and -23.6 .+-. 1.7 .mu.A/cm2, respectively. At 10-4 M, ouabain reduced the short-circuit current on to either side of the chamber. At 10-5 M of furosemide to the aqueous side, the short-circuit current was reduced. Even at 10-3 M, this drug had no effect when applied to the stromal side. Behavior of the dog ciliary body towards these 2 inhibitors was compared with that of the toad and rabbit tissues.