Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) from Guanosine
- 1 May 1995
- journal article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 14 (3) , 337-340
- https://doi.org/10.1080/15257779508012376
Abstract
A convenient synthesis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) from guanosine by chemical transpurination was developed. The isomerization of the 7-isomer to the desired 9-isomer and the purification of the 9-isomer was achieved simply by concentration, heating and further crystallization.Keywords
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