The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard
Open Access
- 1 March 1971
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 25 (1) , 172-181
- https://doi.org/10.1038/bjc.1971.24
Abstract
The effect of cysteine on the immunosuppressive activity of three alkylating agents was tested. Cysteine strongly inhibited the ability of cyclophosphamide and nitrogen mustard to depress the direct plaque-forming cell response of mice to sheep red cells. In contrast, the activity of busulphan was usually potentiated by administration of cysteine. This throws doubt on the hypothesis that busulphan exerts its cytotoxic effects by alkylating thiol groups.Keywords
This publication has 7 references indexed in Scilit:
- The lethal action of monofunctional and bifunctional alkylating agents on T7 coliphageBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
- RELATION BETWEEN PHYSICO-CHEMICAL PROPERTIES AND IMMUNOSUPPRESSIVE EFFECTS OF AN HOMOLOGOUS SERIES OF SULPHONIC ACID ESTERS1967
- Metabolism of cyclophosphamideCancer, 1967
- Protection against the toxicity of alkylating agents by thiols: The mechanism of protection and its relevance to cancer chemotherapyEuropean Journal of Cancer (1965), 1966
- Metabolism of Myleran (1 : 4-Dimethanesulphonyloxybutane)Nature, 1959
- The Action of Chlorambucil (CB. 1348) and Busulphan (Myleran) on the Haemopoietic Organs of the RatBritish Journal of Haematology, 1958
- Reduction of toxicity of nitrogen mustards by cysteineCancer, 1951