Practical and Efficient Enantioselective Borohydride Reduction of Aromatic Ketones Catalyzed by Optically Active Cobalt(II) Complexes Using Pre-Modified Borohydride
- 1 December 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 25 (12) , 1081-1082
- https://doi.org/10.1246/cl.1996.1081
Abstract
A catalytic enantioselective borohydride reduction of aromatic ketones in presence of 0.1-1 mol% of optically active aldiminato cobalt(II) complex catalysts at 0 °C was successfully achieved using precisely pre-modified borohydride with one equivalent each of tetrahydrofurfuryl alcohol, ethanol and NaBH4. The corresponding secondary alcohols were produced in less than 45 min with high enantiomeric excesses (up to 98% ee). The above method was successfully applied to kinetic and dynamic kinetic resolutions of aromatic ketones.Keywords
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