Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo
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Open Access
- 29 May 2005
- journal article
- research article
- Published by Springer Nature in Nature Immunology
- Vol. 6 (7) , 707-714
- https://doi.org/10.1038/ni1210
Abstract
The maturation status of dendritic cells (DCs) determines whether they prime or tolerize T cells. We targeted ovalbumin peptide exclusively to DCs in situ using an antibody to DEC-205 and studied the interaction of DCs with naive CD4+ T cells in tolerizing or priming conditions. We used two-photon microscopy to simultaneously track antigen-specific OT-II T cells, nonspecific T cells and DCs in lymph nodes of living mice. In both tolerance and immunity, OT-II cells arrested on DCs near high endothelial venules beginning shortly after extravasation and regained their baseline speed by 18 h. Thus, early antigen-dependent T cell arrest on DCs is a shared feature of tolerance and priming associated with activation and proliferation.Keywords
This publication has 48 references indexed in Scilit:
- Influenza Virus–induced Dendritic Cell Maturation Is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic ProteinThe Journal of Experimental Medicine, 2003
- Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated ImmunityImmunity, 2003
- Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodesNature Immunology, 2003
- Inducible Transgenic Mice Reveal Resting Dendritic Cells as Potent Inducers of CD8+ T Cell ToleranceImmunity, 2003
- Tolerogenic Dendritic CellsAnnual Review of Immunology, 2003
- Autonomous T cell trafficking examined in vivo with intravital two-photon microscopyProceedings of the National Academy of Sciences, 2003
- SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextranInternational Immunology, 2003
- Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell ToleranceThe Journal of Experimental Medicine, 2002
- Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycleBlood, 2001
- A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph NodesThe Journal of Experimental Medicine, 2000