The Presence of an Alcoholic, Ketonic Derivative of Estrone in Human and Rabbit Blood

Publisher Website
Google Scholar
Abstract
Studies indicate the presence of an intermediate in the metabolism of estrogenic steroid hormones which has not been noticed before. The studies were made on human blood, and on human and rabbit blood diluted by White''s soln. The diluted bloods were used as the perfusing media for human and rabbit organs maintained on a perfusion pump for varying lengths of time. Each perfusion study lasted 24 hrs. The separations of the component estrogens involved the Girard and succinic anhydride reactions. Biologic activity was found in the alcoholic fraction whether or not estrone had been added to the fluids. Addition of estrone during perfusion increased the amt. of material in the alcoholic fraction. It appears reasonable to assume that an alcoholic ketone derivative of estrone is normally present in human and rabbit blood. The compd. appears to be extremely labile.
Keywords