Insulin and glucagon relationships during aging in rats.

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Abstract
Oral glucose tolerance tests were performed under pentobarbital anesthesia in 43 male Wistar rats 2-18 mo. of age. Although any linear correlation was not demonstrated between aging and blood glucose, plasma insulin or glucagon levels, post-glucose levels of blood glucose were significantly suppressed and those of plasma glucagon were significantly elevated at 4-6 mo. of age. No significant difference was found between young (2 mo. of age) and aged rats (12-14 and 17-18 mo. of age) in either blood glucose or plasma insulin levels during oral glucose load. Post-glucose plasma glucagon levels of the aged rats were significantly higher than those of the young ones. Furthermore, comparisons of various kinds of indices among the different age groups, such as insulinogenic index and insulin/glucagon during oral glucose tolerance tests also indicate the significant alteration of glucagon secretion during aging process. Glucose tolerance does not apparently deteriorate during aging process in rats but glucagon responses to oral glucose administration are elevated with aging.

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