Potentiation of Ampicillin Skin Reactions by Allopurinol or Hyperuricemia

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Abstract
Of 4434 hospitalized medical patients who received ampicillin in the absence of allopurinol, 251 (5.9 per cent) developed a rash within 21 days of exposure. Of 252 patients who received ampicillin and allopurinol together, 35 (13.9 per cent) developed a rash. The present data confirm the previously reported increase in rash frequency in patients who receive both ampicillin and allopurinol.