Veränderungen des Kallikrein-Kinin-und des Komplement-Systems bei Angiographien mit nicht-ionischen Kontrastmitteln

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Abstract
To examine alterations of the kallikrein-kinin system and of the complement due to the bolus injection of newer non-ionic contrast agents, venous blood samples were taken before and 3 min after angiography. There were no adverse contrast reactions clinically evident. Prekallikrein, kallikrein inhibition, β-factor XIIa inhibition, C1-esterase inhibitor, C1q, C3, ATIII, HMW-kininogen, fibrinogen and faktor XII were determined. Bolus injection of the contrast medium caused an activation of the kallikrein-kinin system (pp<0.05) indicating an activation of the complement. Our results demonstrate, that angiography causes a significant activation of the kallikrein-kinin as well as of the complement system in spite of the use of newer non-ionic contrast agents.