Oral hydralazine therapy for acute pulmonary embolism and low output state
- 1 October 1981
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 141 (11) , 1537-1538
- https://doi.org/10.1001/archinte.141.11.1537
Abstract
Shortly after pelvic surgery, massive bilateral pulmonary emboli and shock developed in an elderly woman. Despite fluids, dopamine hydrochloride, and heparin sodium, her condition steadily deteriorated. Two trials of hydralazine hydrochloride were given and each was associated with pronounced clinical and hemodynamic improvements. Ninety minutes and 24 hours after the first trial, her pulmonary vascular resistance decreased 44% and 67%, respectively, and cardiac index increased 40% and 90%, respectively. There were insignificant changes in heart rate and blood pressure. The hemodynamic improvements reversed when the hydralazine therapy was stopped but improved again during the second trial. Hydralazine may be of substantial benefit to patients with hemodynamic compromise secondary to pulmonary embolism. (Arch Intern Med1981;141:1537-1538)This publication has 1 reference indexed in Scilit:
- Primary Pulmonary Hypertension Treated with Oral PhentolamineAnnals of Internal Medicine, 1979