Pharmacological observations in patients with nodoventricular pathways.

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Abstract
Patients (3) with accessory nodoventricular pathways and re-entry tachycardia are reported. In all 3 patients the accessory nodoventricular pathway formed the anterograde limb of the re-entry circuit while the His-Purkinje-atrioventricular node axis formed the retrograde limb of the tachycardia in 2 of the patients and a concealed accessory pathway formed the retrograde limb in the remaining patient. All 3 patients also manifested dual anterograde atrioventricular nodal pathways with conduction through the accessory nodoventricular pathways being associated with the atrioventricular nodal fast pathway. Type I antiarrhythmic drugs, especially disopyramide and quinidine, were effective for the treatment of the re-entry tachycardia because of their depressive action on the nodoventricular pathway. .beta.-Blockers were also effective because of their action on the atrioventricular nodal portion of the re-entry circuit in 1 patient and most probably due to atypical (atrioventricular nodal like) properties of a retrogradely conducting accessory pathway in a 2nd patient.