Implication of Creatinine and Gut Flora in the Uremic Syndrome: Induction of "Creatininase" in Colon Contents of the Rat by Dietary Creatinine
- 1 March 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 18 (3) , 280-284
- https://doi.org/10.1093/clinchem/18.3.280
Abstract
"Creatininase" activity was induced in the colon flora of rats by feeding creatinine. Sarcosine and methylamine were tentatively identified as the major products of the enzymic action. A third (unidentified) compound was observed. These compounds and methylguanidine were labeled in the urine of rats given 14CH3-creatinine orally. The results suggest that creatinine should not be considered biologically inert in animals, especially in those with decreased renal function.Keywords
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