The Serological Relationship of the Soluble Antigens of Adenovirus Type 19

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Abstract
Summary The relationship of group-specific (hexon) antigen, type-specific (fibre) antigen, soluble haemagglutinin (dodecon) and purified virus particles of adenovirus 19 was studied by cross complement-fixation, haemagglutination-inhibition and neutralization with antisera prepared against purified antigens. The fibre antigen reacted as an indirect haemagglutinin, producing haemagglutination in the presence of selected heterologous adenovirus immune sera. Dodecon and fibre antigen were closely related, while hexon antigen showed no relationship to fibre and possibly a weak relationship to dodecon antigen. Neutralizing antibodies were found in antisera to hexon and dodecon, but not in fibre antisera.

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