MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632
- 25 October 2003
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 46 (11) , 1532-1542
- https://doi.org/10.1007/s00125-003-1223-4
Abstract
Insulin-induced IRS-1 serine phosphorylation could be physiologically important to regulate insulin action. In a hyperinsulinaemic state such as obesity or Type 2 diabetes, this phosphorylation could be modified and exacerbate insulin resistance. We aimed at identifying serine residues in IRS-1 phosphorylated in response to insulin stimulation and at determining the involved kinases.Keywords
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