One-Pot Synthesis of α-Mono- and α,α-Disubstituted Cyclic Ethers from Lactones
- 5 October 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 17 (10) , 1725-1728
- https://doi.org/10.1246/cl.1988.1725
Abstract
α-Mono- and α,α,-disubstituted cyclic ethers are prepared in good yields by the successive treatment of lactones with t-butyldimethylsiloxy-1-ethoxyethene and silyl nucleophiles (triethylsilane, allyltrimethylsilane, trimethylsilyl cyanide, etc.) in the presence of a catalytic amount of trityl salts such as TrSbCl6, TrSbF6 and TrClO4 or antimony pentachloride combined with chlorotrimethylsilane and tin(II) halide.Keywords
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