Microsatellite Polymorphisms for Chromosome 5 Bands q11.2-q13.3

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Abstract
The genes for spinal muscular atrophy (SMA) and a possible subtype of schizophrenia (SCZD1) have been mapped to chromosome 5q11.2-q13.3. DNA markers have been mapped to 5q11.2–q13.3 using a hybrid cell line deleted for this region [Gilliam et al., Genomics 1989;5:940–944]. Genomic λ clones for these markers facilitated the identification of highly polymorphic microsatelhtes. A total of ten microsatelhtes were identified and sequenced. Of these, seven were found to be polymorphic. Four had polymorphism information content values > 0.7. New polymorphic microsatelhtes were sequenced for D5S76, D5S125, D5S39, D5S127 and HEX-B. Two-point and multipoint analysis in non-CEPH pedigrees confirmed that the microsatelhtes were in tight linkage with each other. These new microsatelhtes will increase the efficiency of linkage analysis for these disorders.

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