Crystallization of Calcium-Calmodulin-Trifluoperazine Complex and an Attempt at Crystallizing Calcium-Free Calmodulin
- 1 June 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 97 (6) , 1815-1818
- https://doi.org/10.1093/oxfordjournals.jbchem.a135242
Abstract
Crystals suitable for X-ray structure analysis were obtained for CaM complexed with both calcium ions and a phenothiazine drug, trifluoperazine (TFP). The TFP/CaM binding ratio in crystals was experimentally determined to be nearly 1. An attempt at crystallizing calcium-free calmodulin (CaM) resulted in rigid but non-birefringent solids which exhibited no X-ray reflections.This publication has 7 references indexed in Scilit:
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