Chronic, recurrent small-vessel cutaneous vasculitis. Clinical experience in 13 patients

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Abstract
The clinical experience in 13 patients with small-vessel cutaneous vasculitis limited to the skin is presented. Within the spectrum hypersensitivity vasculitis, these patients represent a distinctive clinical entity characterized by clinical, laboratory and histopathologic features of the hypersensitivity vasculitis group; chronic and recurrent isolated cutaneous vasculitis eruptions; absence of disease progression to systemic involvement during long-term follow-up; and relative unresponsiveness to immunosuppressive therapy, including treatment with corticosteroids (prednisone) and cyclophosphamide. Because this disease remains limited to the skin, potentially toxic immunosuppressive regimens with prolonged daily corticosteroids or cytotoxic agents should be avoided. Treatment of local symptoms, particularly lower extremity pain, remains a difficult treatment problem in some patients.

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