NISOLDIPINE - A NEW, MORE SELECTIVE CALCIUM CURRENT BLOCKER IN CARDIAC PURKINJE-FIBERS

Google Scholar
  • 1 January 1982
    • journal article
    • research article
    • Vol. 223  (2) , 446-456
Abstract
Nisoldipine is a new dihydropyridine derivative which is structurally related to the Ca current blocker nifedipine. The effects of this new blocker are studied on [calf] Purkinje fiber plateau currents and are compared with the effects of D600 [methoxy verapamil] on the same currents. Like D600, at concentrations of .apprx. 10 .mu.M nisodipine can completely block the slow inward current and contractile activation. As is the case for D600 at these concentrations, nisoldipine reduces the transient outward current. In contrast to D600 and other Ca current blockers, this new compound does not reduce the delayed rectifier. The block of slow inward current by nisoldipine is much less sensitive to membrane potential than is the case for the block of D600 of this current. Nisoldipine is a more selective Ca current blocker than previously studied compounds are, it may be useful both as an experimental and a therapeutic tool.